Comparative Pharmacokinetics of Cefamandole, Cephapirin, and Cephalothin in Healthy Subjects and Effect of Repeated Dosing

Cefamandole nafate, cephapirin, and cephalothin were administered intravenously in crossover fashion to 12 volunteers, in dosages of 2 g every 6 h for 16 doses. Mean peak levels of cefamandole were approximately 50% higher than those of the other agents. The serum concentration curves appeared to de...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Barza, Michael, Melethil, Srikumaran, Berger, Stephen, Ernst, E. Chaim
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1976
Soggetti:	Pharmacology and Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/984783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.3.421
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