Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

Eukaryotic cells execute complex transcriptional programs in which specific loci throughout the genome are regulated in distinct ways by targeted regulatory assemblies. We have applied this principle to generate synthetic CRISPR-based transcriptional programs in yeast and human cells. By extending g...

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Publicat a:Cell
Autors principals: Zalatan, Jesse G., Lee, Michael E., Almeida, Ricardo, Gilbert, Luke A., Whitehead, Evan H., La Russa, Marie, Tsai, Jordan C., Weissman, Jonathan S., Dueber, John E., Qi, Lei S., Lim, Wendell A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297522/
https://ncbi.nlm.nih.gov/pubmed/25533786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.052
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