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CRISPR interference (CRISPRi) for sequence-specific control of gene expression

Sequence-specific control of gene expression on a genome-wide scale is an important approach for understanding gene functions and for engineering genetic regulatory systems. We have recently described an RNA-based method, CRISPR interference (CRISPRi), for targeted silencing of transcription in bact...

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Detalhes bibliográficos
Main Authors: Larson, Matthew H, Gilbert, Luke A, Wang, Xiaowo, Lim, Wendell A, Weissman, Jonathan S, Qi, Lei S
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922765/
https://ncbi.nlm.nih.gov/pubmed/24136345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2013.132
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