Genome-scale perturbation of lncRNA expression using CRISPR interference

CRISPR-mediated interference (CRISPRi), a robust and specific system for programmably repressing transcription, provides a versatile tool for systematically characterizing the function of long non-coding RNAs (lncRNAs). When used with highly parallel, lentiviral pooled screening approaches, CRISPRi...

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Bibliographic Details
Published in:	Methods Mol Biol
Main Authors:	Liu, S John, Horlbeck, Max A, Weissman, Jonathan S, Lim, Daniel A
Format:	Artigo
Language:	Inglês
Published:	2021
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7917014/ https://ncbi.nlm.nih.gov/pubmed/33326085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-0716-1158-6_20
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Genome-scale perturbation of lncRNA expression using CRISPR interference

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