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Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically d...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664290/ https://ncbi.nlm.nih.gov/pubmed/23452860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.02.022 |
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