CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

The genetic interrogation and reprogramming of cells requires methods for robust and precise targeting of genes for expression or repression. The CRISPR-associated catalytically inactive dCas9 protein offers a general platform for RNA-guided DNA targeting. Here we show that fusion of dCas9 to effect...

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Detalhes bibliográficos
Main Authors: Gilbert, Luke A., Larson, Matthew H., Morsut, Leonardo, Liu, Zairan, Brar, Gloria A., Torres, Sandra E., Stern-Ginossar, Noam, Brandman, Onn, Whitehead, Evan H., Doudna, Jennifer A., Lim, Wendell A., Weissman, Jonathan S., Qi, Lei S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770145/
https://ncbi.nlm.nih.gov/pubmed/23849981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.044
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