Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

Eukaryotic cells execute complex transcriptional programs in which specific loci throughout the genome are regulated in distinct ways by targeted regulatory assemblies. We have applied this principle to generate synthetic CRISPR-based transcriptional programs in yeast and human cells. By extending g...

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Publicado no:Cell
Main Authors: Zalatan, Jesse G., Lee, Michael E., Almeida, Ricardo, Gilbert, Luke A., Whitehead, Evan H., La Russa, Marie, Tsai, Jordan C., Weissman, Jonathan S., Dueber, John E., Qi, Lei S., Lim, Wendell A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297522/
https://ncbi.nlm.nih.gov/pubmed/25533786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.052
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