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Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
Eukaryotic cells execute complex transcriptional programs in which specific loci throughout the genome are regulated in distinct ways by targeted regulatory assemblies. We have applied this principle to generate synthetic CRISPR-based transcriptional programs in yeast and human cells. By extending g...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297522/ https://ncbi.nlm.nih.gov/pubmed/25533786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.052 |
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