Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and must retain the ability to bind to host receptors while also diversifying to aid immune evasion. The interaction between CIDRα1 domains of PfEMP1 and endothelial protein C receptor (EPCR) is associated with seve...

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Bibliografske podrobnosti
izdano v:Cell Host Microbe
Main Authors: Lau, Clinton K.Y., Turner, Louise, Jespersen, Jakob S., Lowe, Edward D., Petersen, Bent, Wang, Christian W., Petersen, Jens E.V., Lusingu, John, Theander, Thor G., Lavstsen, Thomas, Higgins, Matthew K.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297295/
https://ncbi.nlm.nih.gov/pubmed/25482433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.11.007
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