Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and must retain the ability to bind to host receptors while also diversifying to aid immune evasion. The interaction between CIDRα1 domains of PfEMP1 and endothelial protein C receptor (EPCR) is associated with seve...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Lau, Clinton K.Y., Turner, Louise, Jespersen, Jakob S., Lowe, Edward D., Petersen, Bent, Wang, Christian W., Petersen, Jens E.V., Lusingu, John, Theander, Thor G., Lavstsen, Thomas, Higgins, Matthew K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297295/
https://ncbi.nlm.nih.gov/pubmed/25482433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.11.007
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