Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1

The pathogenesis of Plasmodium falciparum malaria involves a complex interplay between parasite adhesion and inflammatory response that includes release of cytokines and activation of the endothelium with accompanying release of Angiopoitin 2 (Ang2) to the plasma. A-disintegrin and metalloproteinase...

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Publicado no:Sci Rep
Main Authors: Petersen, Jens E. V., Mkumbaye, Sixbert I., Vaaben, Anna V., Manjurano, Alphaxard, Lyimo, Eric, Kavishe, Reginald A., Mwakalinga, Steven B., Mosha, Jacklin, Minja, Daniel T. R., Lusingu, John P. A., Theander, Thor G., Lavstsen, Thomas, Wang, Christian W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082358/
https://ncbi.nlm.nih.gov/pubmed/27784899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35950
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