Tumor-Penetrating iRGD Peptide Inhibits Metastasis

Tumor-specific tissue-penetrating peptides deliver drugs into extravascular tumor tissue by increasing tumor vascular permeability through interaction with neuropilin (NRP). Here we report that a prototypic tumor-penetrating peptide iRGD (amino acid sequence: CRGDKGPDC) potently inhibits spontaneous...

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Publicado en:Mol Cancer Ther
Main Authors: Sugahara, Kazuki N., Braun, Gary B., de Mendoza, Tatiana Hurtado, Kotamraju, Venkata Ramana, French, Randall P., Lowy, Andrew M., Teesalu, Tambet, Ruoslahti, Erkki
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297196/
https://ncbi.nlm.nih.gov/pubmed/25392370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0366
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