Tumor-penetrating therapy for β5 integrin-rich pancreas cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we report that carcinoma-associated fibroblasts (CAFs) induce β5 integrin expression in tumor cells in a TGF-β dependent manner,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hurtado de Mendoza, Tatiana, Mose, Evangeline S., Botta, Gregory P., Braun, Gary B., Kotamraju, Venkata R., French, Randall P., Suzuki, Kodai, Miyamura, Norio, Teesalu, Tambet, Ruoslahti, Erkki, Lowy, Andrew M., Sugahara, Kazuki N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943581/
https://ncbi.nlm.nih.gov/pubmed/33750829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21858-1
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