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A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity

The accessibility of extravascular tumor tissue to drugs is critical for therapeutic efficacy. We previously described a tumor-targeting peptide (iRGD) that elicits active transport of drugs and macromolecules (covalently coupled or co-administered) across the vascular wall into tumor tissue. Short...

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Detalhes bibliográficos
Main Authors: Pang, Hong-Bo, Braun, Gary B., She, Zhi-Gang, Kotamraju, Venkata R., Sugahara, Kazuki N., Teesalu, Tambet, Ruoslahti, Erkki
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930474/
https://ncbi.nlm.nih.gov/pubmed/24345789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.12.006
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