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A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity
The accessibility of extravascular tumor tissue to drugs is critical for therapeutic efficacy. We previously described a tumor-targeting peptide (iRGD) that elicits active transport of drugs and macromolecules (covalently coupled or co-administered) across the vascular wall into tumor tissue. Short...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3930474/ https://ncbi.nlm.nih.gov/pubmed/24345789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.12.006 |
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