RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2

To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silen...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Zhu, Yuan Xiao, Yin, Hongwei, Bruins, Laura A., Shi, Chang-Xin, Jedlowski, Patrick, Aziz, Meraj, Sereduk, Chris, Kortuem, Klaus Martin, Schmidt, Jessica E., Champion, Mia, Braggio, Esteban, Keith Stewart, A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296009/
https://ncbi.nlm.nih.gov/pubmed/25395420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-577130
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