RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2

To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silen...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Zhu, Yuan Xiao, Yin, Hongwei, Bruins, Laura A., Shi, Chang-Xin, Jedlowski, Patrick, Aziz, Meraj, Sereduk, Chris, Kortuem, Klaus Martin, Schmidt, Jessica E., Champion, Mia, Braggio, Esteban, Keith Stewart, A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296009/
https://ncbi.nlm.nih.gov/pubmed/25395420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-577130
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