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Kinase Regulation by Hydrophobic Spine Assembly in Cancer

A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of the hydrophobic spines by focusing initially on mut...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295384/
https://ncbi.nlm.nih.gov/pubmed/25348715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00943-14
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