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Conformationally Constrained and Nanoparticle Targeted Paclitaxels

Paclitaxel (Taxol(®)) is one of the most important anticancer agents developed over the last 30 years. Its primary mechanism of action is by interaction with the cellular protein tubulin, causing irreversible polymerization to microtubules. A detailed knowledge of this crucial interaction is thus of...

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Publicado en:Pure Appl Chem
Autores principales: Kingston, David G. I., Tamarkin, Lawrence, Paciotti, Giulio F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295212/
https://ncbi.nlm.nih.gov/pubmed/25598555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1351/PAC-CON-11-09-02
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