Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries

[Image: see text] Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement. In this study, we show that by c...

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Vydáno v:ACS Comb Sci
Hlavní autoři: Gao, Yu, Amar, Sabrina, Pahwa, Sonia, Fields, Gregg, Kodadek, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294594/
https://ncbi.nlm.nih.gov/pubmed/25434974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co500154e
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