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Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries

[Image: see text] Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement. In this study, we show that by c...

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Bibliografische gegevens
Gepubliceerd in:ACS Comb Sci
Hoofdauteurs: Gao, Yu, Amar, Sabrina, Pahwa, Sonia, Fields, Gregg, Kodadek, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2014
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294594/
https://ncbi.nlm.nih.gov/pubmed/25434974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co500154e
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