Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage

The neural type I membrane protein Alcadein α (Alcα), is primarily cleaved by amyloid β-protein precursor (APP) α-secretase to generate a membrane-associated carboxyl-terminal fragment (Alcα CTF), which is further cleaved by γ-secretase to secrete p3-Alcα peptides and generate an intracellular cytop...

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Vydáno v:J Biol Chem
Hlavní autoři: Takei, Norio, Sobu, Yuriko, Kimura, Ayano, Urano, Satomi, Piao, Yi, Araki, Yoichi, Taru, Hidenori, Yamamoto, Tohru, Hata, Saori, Nakaya, Tadashi, Suzuki, Toshiharu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294525/
https://ncbi.nlm.nih.gov/pubmed/25406318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.599852
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