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Structural and Functional Characterization of a Ketosteroid Transcriptional Regulator of Mycobacterium tuberculosis
Catabolism of host cholesterol is critical to the virulence of Mycobacterium tuberculosis and is a potential target for novel therapeutics. KstR2, a TetR family repressor (TFR), regulates the expression of 15 genes encoding enzymes that catabolize the last half of the cholesterol molecule, represent...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294509/ https://ncbi.nlm.nih.gov/pubmed/25406313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.607481 |
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