Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme

The aminoglycoside phosphotransferase (APH) APH(4)-Ia is one of two enzymes responsible for bacterial resistance to the atypical aminoglycoside antibiotic hygromycin B (hygB). The crystal structure of APH(4)-Ia enzyme was solved in complex with hygB at 1.95 Å resolution. The APH(4)-Ia structure adap...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stogios, Peter J., Shakya, Tushar, Evdokimova, Elena, Savchenko, Alexei, Wright, Gerard D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Microbiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023493/
https://ncbi.nlm.nih.gov/pubmed/21084294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194266
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