Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

Activity of the aminoglycoside phosphotransferase APH(3’)-Ia leads to resistance to aminoglycoside antibiotics in pathogenic Gram-negative bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescue compromised antibiotics such as aminoglycosides is ta...

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Detalhes bibliográficos
Main Authors: Stogios, Peter J., Spanogiannopoulos, Peter, Evdokimova, Elena, Egorova, Olga, Shakya, Tushar, Todorovic, Nick, Capretta, Alfredo, Wright, Gerard D., Savchenko, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743924/
https://ncbi.nlm.nih.gov/pubmed/23758273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130317
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