The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis

Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor that regulates a large set of genes responsible for c...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ho, Ngoc Anh Thu, Dawes, Stephanie S., Crowe, Adam M., Casabon, Israël, Gao, Chen, Kendall, Sharon L., Baker, Edward N., Eltis, Lindsay D., Lott, J. Shaun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817160/
https://ncbi.nlm.nih.gov/pubmed/26858250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707760
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