Activity of 3-Ketosteroid 9α-Hydroxylase (KshAB) Indicates Cholesterol Side Chain and Ring Degradation Occur Simultaneously in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb), a significant global pathogen, contains a cholesterol catabolic pathway. Although the precise role of cholesterol catabolism in Mtb remains unclear, the Rieske monooxygenase in this pathway, 3-ketosteroid 9α-hydroxylase (KshAB), has been identified as a virulence fa...

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Bibliografske podrobnosti
Main Authors: Capyk, Jenna K., Casabon, Israël, Gruninger, Robert, Strynadka, Natalie C., Eltis, Lindsay D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220451/
https://ncbi.nlm.nih.gov/pubmed/21987574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289975
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