IpdAB, a virulence factor in Mycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase

Mycobacterium tuberculosis (Mtb) grows on host-derived cholesterol during infection. IpdAB, found in all steroid-degrading bacteria and a determinant of pathogenicity, has been implicated in the hydrolysis of the last steroid ring. Phylogenetic analyses revealed that IpdAB orthologs form a clade of...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Crowe, Adam M., Workman, Sean D., Watanabe, Nobuhiko, Worrall, Liam J., Strynadka, Natalie C. J., Eltis, Lindsay D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899439/
https://ncbi.nlm.nih.gov/pubmed/29581275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717015115
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