Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol dioxygenase, HsaC, that cleaves catechols. Immuno-compromised mice infected with a ΔhsaC mutant of M. tuberculosis H37Rv su...

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Autors principals: Yam, Katherine C., D'Angelo, Igor, Kalscheuer, Rainer, Zhu, Haizhong, Wang, Jian-Xin, Snieckus, Victor, Ly, Lan H., Converse, Paul J., Jacobs, William R., Strynadka, Natalie, Eltis, Lindsay D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652662/
https://ncbi.nlm.nih.gov/pubmed/19300498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000344
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