Llwytho...

Modulation of K(2P)2.1 and K(2P)10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation

BACKGROUND AND PURPOSE: The β-receptor antagonist carvedilol blocks a range of ion channels. K(2P)2.1 (TREK1) and K(2P)10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Kisselbach, J, Seyler, C, Schweizer, P A, Gerstberger, R, Becker, R, Katus, H A, Thomas, D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294033/
https://ncbi.nlm.nih.gov/pubmed/25168769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12596
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!