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Modulation of K(2P)2.1 and K(2P)10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation
BACKGROUND AND PURPOSE: The β-receptor antagonist carvedilol blocks a range of ion channels. K(2P)2.1 (TREK1) and K(2P)10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294033/ https://ncbi.nlm.nih.gov/pubmed/25168769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12596 |
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