Modulation of K(2P)2.1 and K(2P)10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation

BACKGROUND AND PURPOSE: The β-receptor antagonist carvedilol blocks a range of ion channels. K(2P)2.1 (TREK1) and K(2P)10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Kisselbach, J, Seyler, C, Schweizer, P A, Gerstberger, R, Becker, R, Katus, H A, Thomas, D
Materialtyp: Artigo
Språk:Inglês
Publicerad: BlackWell Publishing Ltd 2014
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294033/
https://ncbi.nlm.nih.gov/pubmed/25168769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12596
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