Modulation of K(2P)2.1 and K(2P)10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation

BACKGROUND AND PURPOSE: The β-receptor antagonist carvedilol blocks a range of ion channels. K(2P)2.1 (TREK1) and K(2P)10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Kisselbach, J, Seyler, C, Schweizer, P A, Gerstberger, R, Becker, R, Katus, H A, Thomas, D
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294033/
https://ncbi.nlm.nih.gov/pubmed/25168769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12596
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