Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2-APB

BACKGROUND: We have previously shown that the thromboxane (TXA2) receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular calcium in cardiomyocytes. Since TXA2 is an inflammatory mediator and induces direct calcium changes in cardiomy...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Touchberry, Chad D, Silswal, Neerupma, Tchikrizov, Vladimir, Elmore, Christopher J, Srinivas, Shubra, Akthar, Adil S, Swan, Hannah K, Wetmore, Lori A, Wacker, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293009/
https://ncbi.nlm.nih.gov/pubmed/25519194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-73
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