Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

Cardiac hypertrophy, either compensated or decompensated, is associated with cardiomyocyte contractile dysfunction from depressed sarcoplasmic reticulum (SR) Ca(2+) cycling. Normalization of Ca(2+) cycling by ablation or inhibition of the SR inhibitor phospholamban (PLN) has prevented cardiac failur...

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Hlavní autoři: Song, Qiujing, Schmidt, Albrecht G., Hahn, Harvey S., Carr, Andrew N., Frank, Beate, Pater, Luke, Gerst, Mike, Young, Karen, Hoit, Brian D., McConnell, Bradley K., Haghighi, Kobra, Seidman, Christine E., Seidman, Jonathan G., Dorn, Gerald W., Kranias, Evangelia G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC153769/
https://ncbi.nlm.nih.gov/pubmed/12639992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316738
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