Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

Cardiac hypertrophy, either compensated or decompensated, is associated with cardiomyocyte contractile dysfunction from depressed sarcoplasmic reticulum (SR) Ca(2+) cycling. Normalization of Ca(2+) cycling by ablation or inhibition of the SR inhibitor phospholamban (PLN) has prevented cardiac failur...

Full description

Saved in:
Bibliographic Details
Main Authors: Song, Qiujing, Schmidt, Albrecht G., Hahn, Harvey S., Carr, Andrew N., Frank, Beate, Pater, Luke, Gerst, Mike, Young, Karen, Hoit, Brian D., McConnell, Bradley K., Haghighi, Kobra, Seidman, Christine E., Seidman, Jonathan G., Dorn, Gerald W., Kranias, Evangelia G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153769/
https://ncbi.nlm.nih.gov/pubmed/12639992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316738
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items