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BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice

BACKGROUND AND PURPOSE: Buprenorphine is a potent analgesic with high affinity at μ, δ and κ and moderate affinity at nociceptin opioid (NOP) receptors. Nevertheless, NOP receptor activation modulates the in vivo activity of buprenorphine. Structure activity studies were conducted to design buprenor...

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書誌詳細
出版年:Br J Pharmacol
主要な著者: Khroyan, T V, Wu, J, Polgar, W E, Cami-Kobeci, G, Fotaki, N, Husbands, S M, Toll, L
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292977/
https://ncbi.nlm.nih.gov/pubmed/24903063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12796
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