載入...
BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice
BACKGROUND AND PURPOSE: Buprenorphine is a potent analgesic with high affinity at μ, δ and κ and moderate affinity at nociceptin opioid (NOP) receptors. Nevertheless, NOP receptor activation modulates the in vivo activity of buprenorphine. Structure activity studies were conducted to design buprenor...
Na minha lista:
| 發表在: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Publishing Ltd
2015
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292977/ https://ncbi.nlm.nih.gov/pubmed/24903063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12796 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|