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Incorporation of ABCB1-mediated transport into a physiologically-based pharmacokinetic model of docetaxel in mice
Docetaxel is one of the most widely used anticancer agents. While this taxane has proven to be an effective chemotherapeutic drug, noteworthy challenges exist in relation to docetaxel administration due to the considerable interindividual variability in efficacy and toxicity associated with the use...
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| Publicado no: | J Pharmacokinet Pharmacodyn |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292804/ https://ncbi.nlm.nih.gov/pubmed/23616082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-013-9317-1 |
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