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Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice

BACKGROUND: Perchloroethylene (perc) induced target organ toxicity has been associated with tissue-specific metabolic pathways. Previous physiologically-based pharmacokinetic (PBPK) modeling of perc accurately predicted oxidative metabolites but suggested the need to better characterize glutathione...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Dalaijamts, Chimeddulam, Cichocki, Joseph A., Luo, Yu-Syuan, Rusyn, Ivan, Chiu, Weihsueh A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051410/
https://ncbi.nlm.nih.gov/pubmed/29857080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.05.033
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