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Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795

Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by...

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Bibliografiska uppgifter
Huvudupphovsmän: Haňka, L. J., Gerpheide, S. A., Spieles, P. R., Martin, D. G., Belter, P. A., Coleman, T. A., Meyer, H. F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1975
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC429230/
https://ncbi.nlm.nih.gov/pubmed/1155921
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