Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795

Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Haňka, L. J., Gerpheide, S. A., Spieles, P. R., Martin, D. G., Belter, P. A., Coleman, T. A., Meyer, H. F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1975
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429230/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1155921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.7.6.807
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!