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Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795

Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Haňka, L. J., Gerpheide, S. A., Spieles, P. R., Martin, D. G., Belter, P. A., Coleman, T. A., Meyer, H. F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1975
Schlagworte:
Articles
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429230/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1155921/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.7.6.807
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