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Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795
Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1975
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC429230/ https://ncbi.nlm.nih.gov/pubmed/1155921 |
| Oznake: |
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