Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

[Image: see text] A novel Type II kinase inhibitor chemotype has been identified for maternal embryonic leucine zipper kinase (MELK) using structure-based ligand design. The strategy involved structural characterization of an induced DFG-out pocket by protein–ligand X-ray crystallography and incorpo...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Johnson, Christopher N., Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E., Day, Phillip J., Frederickson, Martyn, Freyne, Eddy J. E., Gilissen, Ron A. H. J., Hamlett, Christopher C. F., Howard, Steven, Meerpoel, Lieven, Mevellec, Laurence, McMenamin, Rachel, Pasquier, Elisabeth, Patel, Sahil, Rees, David C., Linders, Joannes T. M.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291807/
https://ncbi.nlm.nih.gov/pubmed/25589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001273
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