Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

[Image: see text] A novel Type II kinase inhibitor chemotype has been identified for maternal embryonic leucine zipper kinase (MELK) using structure-based ligand design. The strategy involved structural characterization of an induced DFG-out pocket by protein–ligand X-ray crystallography and incorpo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Johnson, Christopher N., Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E., Day, Phillip J., Frederickson, Martyn, Freyne, Eddy J. E., Gilissen, Ron A. H. J., Hamlett, Christopher C. F., Howard, Steven, Meerpoel, Lieven, Mevellec, Laurence, McMenamin, Rachel, Pasquier, Elisabeth, Patel, Sahil, Rees, David C., Linders, Joannes T. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291807/
https://ncbi.nlm.nih.gov/pubmed/25589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001273
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia