Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

[Image: see text] A novel Type II kinase inhibitor chemotype has been identified for maternal embryonic leucine zipper kinase (MELK) using structure-based ligand design. The strategy involved structural characterization of an induced DFG-out pocket by protein–ligand X-ray crystallography and incorpo...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:ACS Med Chem Lett
Autors principals: Johnson, Christopher N., Adelinet, Christophe, Berdini, Valerio, Beke, Lijs, Bonnet, Pascal, Brehmer, Dirk, Calo, Frederick, Coyle, Joseph E., Day, Phillip J., Frederickson, Martyn, Freyne, Eddy J. E., Gilissen, Ron A. H. J., Hamlett, Christopher C. F., Howard, Steven, Meerpoel, Lieven, Mevellec, Laurence, McMenamin, Rachel, Pasquier, Elisabeth, Patel, Sahil, Rees, David C., Linders, Joannes T. M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291807/
https://ncbi.nlm.nih.gov/pubmed/25589926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001273
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars