MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Yang, Huan, Wang, Haichao, Ju, Zhongliang, Ragab, Ahmed A., Lundbäck, Peter, Long, Wei, Valdes-Ferrer, Sergio I., He, Mingzhu, Pribis, John P., Li, Jianhua, Lu, Ben, Gero, Domokos, Szabo, Csaba, Antoine, Daniel J., Harris, Helena E., Golenbock, Doug T., Meng, Jianmin, Roth, Jesse, Chavan, Sangeeta S., Andersson, Ulf, Billiar, Timothy R., Tracey, Kevin J., Al-Abed, Yousef
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2015
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291531/
https://ncbi.nlm.nih.gov/pubmed/25559892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141318
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