MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Yang, Huan, Wang, Haichao, Ju, Zhongliang, Ragab, Ahmed A., Lundbäck, Peter, Long, Wei, Valdes-Ferrer, Sergio I., He, Mingzhu, Pribis, John P., Li, Jianhua, Lu, Ben, Gero, Domokos, Szabo, Csaba, Antoine, Daniel J., Harris, Helena E., Golenbock, Doug T., Meng, Jianmin, Roth, Jesse, Chavan, Sangeeta S., Andersson, Ulf, Billiar, Timothy R., Tracey, Kevin J., Al-Abed, Yousef
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291531/
https://ncbi.nlm.nih.gov/pubmed/25559892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141318
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