The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation

BACKGROUND: Extra-corpuscular hemoglobin is an endogenous factor enhancing inflammatory tissue damage, a process counteracted by the hemoglobin-binding plasma protein haptoglobin composed of alpha and beta subunits connected by disulfide bridges. Recent studies established that haptoglobin also bind...

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Bibliographic Details
Published in:J Intern Med
Main Authors: Yang, Huan, Wang, Haichao, Wang, Yongjun, Addorisio, Meghan, Li, Jianhua, Postiglione, Michael J., Chavan, Sangeeta S., Al-Abed, Yousef, Antoine, Daniel J., Andersson, Ulf, Tracey, Kevin J.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477782/
https://ncbi.nlm.nih.gov/pubmed/28464519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/joim.12619
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