The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88

Extracellular high-mobility group box 1 (HMGB1) (disulfide form), via activation of toll-like receptor 4 (TLR4)-dependent signaling, is a strong driver of pathologic inflammation in both acute and chronic conditions. Identification of selective inhibitors of HMGB1-TLR4 signaling could offer novel th...

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Publicado no:Mol Med
Main Authors: Pribis, John P, Al-Abed, Yousef, Yang, Huan, Gero, Domokos, Xu, Hongbo, Montenegro, Marcelo F, Bauer, Eileen M, Kim, Sodam, Chavan, Sangeeta S, Cai, Changchun, Li, Tunliang, Szoleczky, Petra, Szabo, Csaba, Tracey, Kevin J, Billiar, Timothy R
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749497/
https://ncbi.nlm.nih.gov/pubmed/26349060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00197
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