The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88

Extracellular high-mobility group box 1 (HMGB1) (disulfide form), via activation of toll-like receptor 4 (TLR4)-dependent signaling, is a strong driver of pathologic inflammation in both acute and chronic conditions. Identification of selective inhibitors of HMGB1-TLR4 signaling could offer novel th...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Mol Med
Hoofdauteurs: Pribis, John P, Al-Abed, Yousef, Yang, Huan, Gero, Domokos, Xu, Hongbo, Montenegro, Marcelo F, Bauer, Eileen M, Kim, Sodam, Chavan, Sangeeta S, Cai, Changchun, Li, Tunliang, Szoleczky, Petra, Szabo, Csaba, Tracey, Kevin J, Billiar, Timothy R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Feinstein Institute Press 2015
Onderwerpen:
Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749497/
https://ncbi.nlm.nih.gov/pubmed/26349060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00197
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items