Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening

High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein, is released into the circulation during sterile inflammation (e.g. arthritis, trauma) and circulatory shock. It participates in the pathogenesis of delayed inflammatory responses and organ dysfunction. While several molecules...

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Detalhes bibliográficos
Main Authors: Gerö, Domokos, Szoleczky, Petra, Módis, Katalin, Pribis, John P., Al-Abed, Yousef, Yang, Huan, Chevan, Sangeeta, Billiar, Timothy R., Tracey, Kevin J., Szabo, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682954/
https://ncbi.nlm.nih.gov/pubmed/23799067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065994
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