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Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity
The small Rho GTPase Cdc42, known to interact with Wiskott–Aldrich syndrome (WAS) protein, is an important regulator of actin remodeling. Here, we show that genetic ablation of Cdc42 exclusively in the B cell lineage is sufficient to render mice unable to mount antibody responses. Indeed Cdc42-defic...
Shranjeno v:
| izdano v: | J Exp Med |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291523/ https://ncbi.nlm.nih.gov/pubmed/25547673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141143 |
| Oznake: |
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