A switch from canonical to noncanonical autophagy shapes B cell responses

Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of...

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Udgivet i:Science
Main Authors: Martinez-Martin, Nuria, Maldonado, Paula, Gasparrini, Francesca, Frederico, Bruno, Aggarwal, Shweta, Gaya, Mauro, Tsui, Carlson, Burbage, Marianne, Keppler, Selina Jessica, Montaner, Beatriz, Jefferies, Harold B.J., Nair, Usha, Zhao, Yan G., Domart, Marie-Charlotte, Collinson, Lucy, Bruckbauer, Andreas, Tooze, Sharon A., Batista, Facundo D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805088/
https://ncbi.nlm.nih.gov/pubmed/28183981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3908
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